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Description
Human IL-8 OneStep ELISA KitProduct Specification Antigen IL 8 Immunogen Recombinant Protein Antibody Type Recombinant mAb Reactivity Hu Purification Protein A Stability & Storage 2 to 8 C as supplied. Kit Precision Intra assay: 3. 3% Inter assay: 4. 4% Sample type Cell culture supernatant, Serum, Plasm Assay type Sandwich (quantitative) Sensitivity 2. 966 pg ml Range 3. 9 pg mL 250 pg mL Recovery Cell culture supernatant: 86% Serum: 108% Plasm: 96% Assay time 60 minutes Species
Product Specification
| Antigen | IL-8 |
| Immunogen | Recombinant Protein |
| Antibody Type | Recombinant mAb |
| Reactivity | Hu |
| Purification | Protein A |
| Stability & Storage | 2 to 8 °C as supplied. |
Kit
| Precision | Intra-assay: 3.3%； Inter-assay: 4.4% |
| Sample type | Cell culture supernatant, Serum, Plasm |
| Assay type | Sandwich (quantitative) |
| Sensitivity | 2.966 pg/ml |
| Range | 3.9 pg/mL – 250 pg/mL |
| Recovery | Cell culture supernatant: 86% Serum: 108% Plasm: 96% |
| Assay time | 60 minutes |
| Species reactivity | Human |
| NIBSC convert | The dose response curve of the International Standard (89/520) parallels the OneStep standard curve. To convert sample values obtained with the kit to approximate NIBSC (89/520) units, use the following equation: NIBSC (89/520) approximate value (IU/mL) = 0.001 x OneStep Human IL-8 value (pg/mL). |
Background
Interleukin 8 (IL-8 or chemokine (C-X-C motif) ligand 8, CXCL8) is a chemokine produced by macrophages and other cell types such as epithelial cells, airway smooth muscle cells and endothelial cells. Endothelial cells store IL-8 in their storage vesicles, the Weibel-Palade bodies. IL-8 is initially produced as a precursor peptide of 99 amino acids which then undergoes cleavage to create several active IL-8 isoforms. In culture, a 72 amino acid peptide is the major form secreted by macrophages. Interleukin-8 is a key mediator associated with inflammation where it plays a key role in neutrophil recruitment and neutrophil degranulation. IL-8 has also been implied to have a role in colorectal cancer by acting as an autocrine growth factor for colon carcinoma cell lines or the promotion of division and possible migration by cleaving metalloproteinase molecules. It has also been shown that IL-8 plays an important role in chemoresistance of malignant pleural mesothelioma by inducing expression of transmembrane transporters.
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