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Description
Histone H3 Recombinant Rabbit mAb (SDT-266-44)Product Specification Host Rabbit Antigen Histone H3 Synonyms Histone H3. 1 Immunogen Synthetic Peptide Location Nucleus Accession P68431 Clone Number SDT 266 44 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IP, IF, ICFCM, ChIP Reactivity Hu, Ms, Rt Positive Sample HEK293, HeLa, NIH3T3, mouse brain, C6, rat liver, human brain, human spleen, human prostate, human breast cancer, human hepatocellular carcinoma, mouse brain, rat
Product Specification
| Host | Rabbit |
| Antigen | Histone H3 |
| Synonyms | Histone H3.1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | P68431 |
| Clone Number | SDT-266-44 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IP, IF, ICFCM, ChIP |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK293, HeLa, NIH3T3, mouse brain, C6, rat liver, human brain, human spleen, human prostate, human breast cancer, human hepatocellular carcinoma, mouse brain, rat brain |
| Predicted Reactivity | Bv, Dr, C.el, Pl |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied. |
Dilution
| application | dilution | species |
| WB | 1:5000-1:10000 | Hu, Ms, Rt |
| IP | 1:50 | Hu, Ms, Rt |
| IHC-P | 1:4000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu, Ms, Rt |
| IF | 1:500 | Hu, Ms, Rt |
| ICFCM | 1:500 | Hu, Ms, Rt |
| ChIP | 1:20~1:50 | Hu, Ms, Rt |
Background
Histone H3 is a critical component of the nucleosome, which is the basic unit of chromatin. It plays a vital role in the regulation of gene transcription and is subject to various post-translational modifications (PTMs) that affect chromatin structure and gene expression. The H3 family includes several variants, with H3.1, H3.2, and H3.3 being the most well-known. H3.1 and H3.2 are deposited during DNA replication, while H3.3 can be deposited independently of DNA replication and is incorporated throughout the cell cycle2. Post-translational modifications of Histone H3, particularly on the N- and C-terminal tails, can influence the interaction between histones and DNA, as well as with other chromatin factors. These modifications can either promote a relaxed chromatin state that allows gene transcription or lead to a condensed chromatin state that typically suppresses transcription.
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