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Description
Alexa Fluor® 488 Rat Anti-Human CD289 Antibody (S-3019)Product Specification Host Rat Antigen CD289 Synonyms Toll like receptor 9; TLR9 Location Endoplasmic reticulum membrane Accession Q9NR96 Clone Number S 3019 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation Alexa Fluor 488 Physical Appearance Liquid Storage Buffer PBS, 1% BSA, 0. 3% Proclin 300 Stability & Storage 12 months from date of receipt
Product Specification
| Host | Rat |
| Antigen | CD289 |
| Synonyms | Toll-like receptor 9; TLR9 |
| Location | Endoplasmic reticulum membrane |
| Accession | Q9NR96 |
| Clone Number | S-3019 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 488 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD289, also known as Toll-like receptor 9 (TLR9), is a ~115-120 kDa intracellular pattern-recognition receptor of the Toll-like receptor family that is preferentially expressed in immune-cell-rich tissues such as spleen, lymph node, bone marrow, and peripheral blood leukocytes; it senses unmethylated CpG dinucleotides in bacterial DNA and, upon activation via the adaptor protein MyD88, triggers NF-κB signaling and subsequent production of inflammatory cytokines, thereby orchestrating a T-helper-1-like innate immune response, as evidenced by impaired splenocyte proliferation, macrophage cytokine release, and dendritic-cell maturation in TLR9-deficient mice.
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