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Description
Acetyl-CoA Carboxylase Recombinant Rabbit mAb (S-2220-96)Product Specification Host Rabbit Antigen Acetyl CoA Carboxylase Synonyms Acetyl CoA carboxylase 1; ACC1; Acetyl Coenzyme A carboxylase alpha (ACC alpha); ACAC; ACCA; ACACA Immunogen Synthetic Peptide Location Cytoplasm Accession Q13085 Clone Number S 2220 96 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HEK 293, A431, HeLa, HepG2, NIH 3T3, mouse brain, C6, rat brain Predicted Reactivity Bv,
Product Specification
| Host | Rabbit |
| Antigen | Acetyl-CoA Carboxylase |
| Synonyms | Acetyl-CoA carboxylase 1; ACC1; Acetyl-Coenzyme A carboxylase alpha (ACC-alpha); ACAC; ACCA; ACACA |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | Q13085 |
| Clone Number | S-2220-96 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, A431, HeLa, HepG2, NIH/3T3, mouse brain, C6, rat brain |
| Predicted Reactivity | Bv, Ck, Sh |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:500 | Hu, Ms, Rt |
| ICC | 1:500 | Ms |
Background
Acetyl-CoA Carboxylase (ACC) is a crucial metabolic enzyme that plays a central role in fatty acid metabolism. It catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC exists in two isoforms: ACC1 (ACACA), primarily localized in the cytosol and regulating fatty acid synthesis, and ACC2 (ACACB), which is associated with the outer mitochondrial membrane. The malonyl-CoA produced by ACC2 inhibits carnitine palmitoyltransferase-1 (CPT-1), thereby regulating fatty acid β-oxidation. The enzyme is tightly controlled by multiple mechanisms, including allosteric regulation (activation by citrate, inhibition by long-chain acyl-CoA), reversible phosphorylation (inactivation by AMPK and PKA), and transcriptional regulation (e.g., SREBP-1c-mediated expression upregulation). Due to its pivotal role in energy metabolism, ACC is a potential therapeutic target for obesity, diabetes, and cancer, with inhibitors (e.g., TOFA, ND-630) currently under investigation. Additionally, plant and bacterial ACCs are targets for herbicides (e.g., aryloxyphenoxypropionates) and antibiotics, highlighting their broad biological significance.
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