SKU: 9717536427

Biotinylated B7-1 Fc&Avi Tag Protein, Human

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Description

Biotinylated B7-1 Fc&Avi Tag Protein, HumanProduct Specification Species Human Antigen B7 1 Synonyms CD80,B7,B7 1,B7. 1,BB1,CD28LG,CD28LG1,LAB7 Accession P33681 1 Amino Acid Sequence Val35 Asn242, with C terminal Human IgG1 Fc &Avi tag

Product Specification


Species Human
Antigen B7-1
Synonyms CD80,B7,B7-1,B7.1,BB1,CD28LG,CD28LG1,LAB7
Accession P33681-1
Amino Acid Sequence

Val35-Asn242, with C-terminal Human IgG1 Fc &Avi tag

VIHVTKEVKEVATLSCGHNVSVEELAQTRIYWQKEKKMVLTMMSGDMNIWPEYKNRTIFDITNNLSIVILALRPSDEGTYECVVLKYEKDAFKREHLAEVTLSVKADFPTPSISDFEIPTSNIRRIICSTSGGFPEPHLSWLENGEELNAINTTVSQDPETELYAVSSKLDFNMTTNHSFMCLIKYGHLRVNQTFNWNTTKQEHFPDNIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGKGLNDIFEAQKIEWHE
Expression System HEK293
Molecular Weight

72-80kDa (Reducing)
Purity ＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Conjugation Biotin
Tag Human Fc Tag, Avi Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, pH7.4
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1.Carin C. Stamper, Yan Zhang, James F. Tobin,David V. Erbe, Shinji Ikemizu, Simon J. Davis, Mark L. Stahl, Jasbir Seehra,William S. Somers & Lidia Mosyak: Crystal structure of the B7-1/CTLA-4complex that inhibits human immune responses, Nature volume 410, pages608–611 (2001).

Background

As the first identified B7 family member, CD80 is widely expressed in a broad spectrum of tissues, even on some malignant tumor cells, thereby suggesting the potential mechanism of immune evasion of tumor cells.CD80 is recognized as one of the most potent costimulatory molecules by which immune cells limit malignant growth. It is upregulated upon cell stress and it is critical for efficacious immune surveillance during carcinogenesis. Low surface expression of CD80 was reported as an immune escape mechanism of colon carcinoma; on the other hand, its expression resulted enhanced in high-frequency microsatellite instability (MSI) colorectal cancers, a CRC subtype which is highly immunogenic and associated with a better prognosis. Both in vivo and in vitro studies showed that the upregulation of CD80 on tumor cell surface successfully activates antitumor immune responses, while its expression is frequently lost during tumor progression probably due to selective pressure by the immune system. Thus, to develop effective approaches for cancer immunotherapy, strategies for enhancing CD80 expression in tumors are urgently required.

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SKU: 9717536427

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4.4 ★★★★★
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Meg
Lowell, US
★★★★★ 5
A Rich and Wonderful Pictorial Biography
Format: Paperback
This is a beautiful book that tells Ghandi's story through wonderful photographs and a simple and elucidating text. Ghandi appears os a struggling human being who changes himself through hard work. It really is a story of transformation, and it's very well told here. I liked it so well, I used it as part of our study on world revolutions when I was teaching ninth grade last year, and the students also liked it very much.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 21, 2013
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greg brown
Birmingham, US
★★★★★ 4
A Tool for Study
Format: Kindle
Though this book feels like it has been cobbled together from different sources it provides a sense of Gandhi's spiritual growth and the sources for it. His ideas and principles are clearly and often repeatedly stated offering the student the benefit of repetition in varied words. I'll be reading it again and again to extract a summary of those. Recommended for beginning Gandhi explorers.
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Reviewed in the United States on May 16, 2016
G
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GILES S RYAN
Draper, US
★★★★★ 5
Off the couch and on the road
Format: Kindle
Even those who are happy in their circumstance may find themselves discontented with the sameness of their days. An adventure will relieve this, and perhaps we can make the adventure happen, and yet the sameness of our days is the very thing that holds us back. But then we read how someone actually did it, had a true adventure to match the best of our daydreams, and we think, I could do that, too! Beth Jusino’s Camino memoir is for everyone who has ever considered doing something extraordinary, something beyond everyday life. She freely admits her life was sedentary — as couch-bound as you or I — but then the notion of the Camino grew from daydream to impulse, and then became irresistible, and she was fortunate to have a husband who gladly came along. It’s a book of astonishing quality, the words well-chosen, each page proof of her craft. She engages us not only with her physical ordeal (which is considerable, until she finds better shoes along the way), but also with her wonderment at the things she sees, the people she meets on the way, and we are compelled along, turning each page to see what happens next. Her story is not only rich in anecdote but also in the wealth of reflection on what she sees and hears along the way. Some particular scenes that stay fixed in memory are her encounters with a flock of sheep she meets at just the point when she needs them — a Camino miracle! — and also her descriptions of the great storks in their huge nests on all the church steeples and other high points along the way. Again and again I marked passages in the text so that I may come back and enjoy them once more. It’s also a love story, and the measure of this is the way we begin to anticipate her moments of particular challenge when her husband will do whatever needs doing or say whatever she needs to hear. It’s his story as well as hers, and she knows this and sets it down, and in so doing, tells us that perhaps she could not have finished her journey without him. Those who have walked any part of the road to Santiago will relive moments in familiar places and perhaps see what they missed the first time along the way and gain a new insight, a fresh view of what they overlooked before. And they may think, yes, I’ll go again! But if you’ve never had an adventure and Santiago is no more than the stuff of your daydreams, if you have so far only imagined such an undertaking, if the sameness of your days holds you back, then read this book. Then go out and do it. But make sure you buy the right shoes.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 27, 2021
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Maggie
Louisville, US
★★★★★ 4
Walking from La Puy to Finisterre...a well written memoir
Format: Paperback
The key to writing a Camino book--at least from this reader's perspective--it to have a well-written, well-edited, and unique personal account of the adventure. I've read many Camino books that lack these three elements. WTTEOTW has all three elements and is a great addition to anyone's Camino library. The book is paced nicely and makes for an easy read. I was amused that the author had spent considerable time preparing for this trip yet seemed not to have absorbed some important information prior to the trip--e.g. appropriate footwear, the scramble for nightly accommodations, the frustrations that commonly occur while traveling in unfamiliar cultures. Her adjustments along the way provide humor and insight into preparing for things we've not yet experienced in our own lives.
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Reviewed in the United States on January 8, 2019
G
Verified Purchase
Girl On Bicycle
Fort Morgan, US
★★★★★ 5
really enjoyable
Format: Kindle
I'm thinking of doing the French route myself (starting in Saint-Jean-Pied-de-Port) and have been inhaling other people's stories of the route, whether blog or book form. The writing is engaging, and both funny and touching in places. I liked that the author is willing to note her own faults as much of those of others', but noted the strengths of herself and everyone around her as well. And her love for her husband jumped off the page, which I really appreciated! About halfway through the author's time in Spain I found myself on google maps--a surprising portion of the Camino is available on street view!--and yeah, now I *really* want to go. I'm thinking spring of 2023. Fingers crossed. EDIT: I read the book and wrote this review in late fall of 2021. It is currently March of 2023. I'm flying to France on April 17th, to start in St. Jean Pied de Port. :D EDIT, number two: The Camino was awesome, and I will probably do it again in a few years, and it was fun to reread this book after doing the Camino and be able to remember so many of the places she talks about. <3
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 2, 2021

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